(4-nitrophenyl)methanesulfonyl chloride(CAS#4025-75-6)
| Risk Codes | R14 – Reacts violently with water R29 – Contact with water liberates toxic gas R34 – Causes burns R22 – Harmful if swallowed |
| Safety Description | S22 – Do not breathe dust. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S30 – Never add water to this product. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN3261 |
| Hazard Class | 8 |
| Packing Group | II |
Introduction
(4-nitrophenyl)methanesulfonyl chloride is an organic compound with a chemical formula of C7H6ClNO5S. It is a light yellow crystal with a spicy smell. The following is a detailed description of the nature, use, preparation and safety information of (4-nitrophenyl)methanesulfonyl chloride:
Nature:
-Appearance: light yellow crystal
-Odor: Spicy smell
-Melting point: about 130-132°C
-Boiling Point: 273-275°C
-Density: 1.54g/cm³ (20°C)
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and ethanol, insoluble in water
Use:
- (4-nitrophenyl)methanesulfonyl chloride is a commonly used organic synthesis reagent, which can be used to prepare other compounds, such as acylating agents and chlorinated reagents.
-In the field of medicinal chemistry and organic synthesis, it is usually used as a reagent to quench amine groups, which can convert amine groups into sulfonyl chloride functional groups to initiate reactions.
-It can also be used to synthesize biologically active compounds, such as drugs and dyes.
Preparation Method:
General method for preparing (4-nitrophenyl)methanesulfonyl chloride:
1. At low temperature, in the presence of sodium carbonate or potassium carbonate, p-nitrotoluene is reacted with sulfonyl chloride.
2. After completion of the reaction, crystals of the product were obtained by cooling and filtration.
Safety Information:
- (4-nitrophenyl)methanesulfonyl chloride irritant to skin, eyes and respiratory tract, rinse with plenty of water immediately after contact and seek medical help.
-it is a pungent odor substances, the operation should pay attention to avoid inhalation of its vapor.
-It is necessary to operate in a well-ventilated area and wear suitable protective equipment, such as gloves, glasses and protective masks.
-Keep away from fire and oxidant to avoid contact with combustibles.
-Storage should be sealed and placed in a cool, dry place, away from fire and acid.
