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4-Hydroxybenzyl alcohol(CAS#623-05-2)

Chemical Property:

Molecular Formula C7H8O2
Molar Mass 124.14
Density 1.1006 (rough estimate)
Melting Point 114-122°C(lit.)
Boling Point 251-253°C
Flash Point 251-253°C
JECFA Number 955
Water Solubility Soluble in water (6.7 mg/ml at 20°C), dioxane (100 mg/ml), 1N NaOH (50 mg/ml), DMSO, and methanol.
Solubility Soluble in methanol, ethanol, DMSO and other organic solvents.
Vapor Presure 0.0104mmHg at 25°C
Appearance Pink, beige (crystalline powder)
Color Pink to beige
BRN 1858967
pKa pK1:9.82 (25°C)
Storage Condition Store below +30°C.
Sensitive Light Sensitive/Air Sensitive
Refractive Index 1.5035 (estimate)
MDL MFCD00004658
Physical and Chemical Properties melting point 110-112°C
Use Used as an intermediate in organic synthesis
In vitro study 4-Hydroxybenzyl alcohol inhibits proliferation of eEND2 cells and suppresses the migration of eEND2 cells, accompanied by inhibition of actin filament reorganization. 4-Hydroxybenzyl alcohol induces apoptotic death of tumor cells.
In vivo study 4-Hydroxybenzyl alcohol possesses antiangiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production. 4-Hydroxybenzyl alcohol (200 mg/kg) efficiently inhibits growth and angiogenesis of developing tumors. 4-Hydroxybenzyl alcohol ameliorates ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect may be partly related to attenuate apoptosis pathway.

Product Detail

Product Tags

Hazard Symbols Xi – Irritant
Risk Codes R36 – Irritating to the eyes
R36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25 – Avoid contact with skin and eyes.
S36 – Wear suitable protective clothing.
WGK Germany 3
RTECS DA4796800
FLUKA BRAND F CODES 8-9-23
HS Code 29072900
Hazard Note Irritant/Keep Cold/Air Sensitive/Light Sensitive

 

Introduction

Hydroxybenzyl alcohol is an organic compound with a chemical structure of C6H6O2, commonly known as phenol methanol. Here are some common properties, uses, preparation methods and safety information about hydroxybenzyl alcohol:

 

Quality:

Appearance: Colorless to yellowish solid or mucous liquid.

Solubility: Soluble in organic solvents such as water, alcohol and ether.

 

Use:

Preservatives: It has antibacterial and antiseptic properties, and hydroxybenzyl alcohol is also used as a wood preservative.

 

Method:

Hydroxybenzyl alcohol is usually produced by the reaction of para-hydroxybenzaldehyde with methanol. The reaction can be catalyzed by an oxidizing agent, such as the catalyst Cu(II.) or ferric chloride(III.). The reaction is generally carried out at room temperature.

 

Safety Information:

Hydroxybenzyl alcohol has a lower toxicity, but care is still required to handle it safely.

In case of contact with skin, rinse immediately with plenty of water. If swallowed, seek medical attention promptly.

Contact with oxidants, acids, and phenols should be avoided during handling and storage to prevent dangerous reactions.

When using or storing, it should be kept away from open flames or high temperatures to prevent fire.


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