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4-Hydroxyacetophenone CAS 99-93-4

Chemical Property:

Molecular Formula C8H8O2
Molar Mass 136.15
Density 1.109
Melting Point 132-135°C(lit.)
Boling Point 147-148°C3mm Hg(lit.)
Flash Point 166 °C
JECFA Number 2040
Water Solubility 10 g/L (22 ºC)
Solubility Soluble in ethanol and ether, slightly soluble in water
Vapor Presure 0.002Pa at 20℃
Appearance White to off-white (Solid)
Specific Gravity 1.109
Color Almost white to beige
BRN 774355
pKa 8.05(at 25℃)
Storage Condition Store below +30°C.
Sensitive Easily absorbing moisture
Refractive Index 1.5577 (estimate)
MDL MFCD00002359
Physical and Chemical Properties White crystals
soluble in hot water, methanol, ether, acetone, insoluble in petroleum ether
Use Raw materials for the manufacture of choleretic drugs and other organic synthesis

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Risk and Safety

Risk Codes R36/37/38 – Irritating to eyes, respiratory system and skin.
R22 – Harmful if swallowed
Safety Description S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37 – Wear suitable protective clothing and gloves.
S37/39 – Wear suitable gloves and eye/face protection
S24/25 – Avoid contact with skin and eyes.
S22 – Do not breathe dust.
S36 – Wear suitable protective clothing.
WGK Germany 3
RTECS PC4959775
TSCA Yes
HS Code 29145000
Hazard Note Irritant

99-93-4 - Reference

Reference

Show more
1. Yu Honghong, Gao Xiaoyan. Based on UPLC-Q-TOF/MS ~ E, rapid analysis of chemical constituents in mianyinchen [J]. Cen…

 

Overview p-hydroxyacetophenone, because its molecule contains hydroxyl and ketone groups on the benzene ring, therefore, it is often used as an intermediate in organic synthesis to react with other compounds to synthesize many important substances. Generally used for the synthesis of pharmaceutical intermediates (α-bromo-p-hydroxyacetophenone, choleretic drugs, antipyretic analgesics and other drugs), Other (spices, feed, etc.; Pesticides, dyes, liquid crystal materials, etc.).
Application p-hydroxyacetophenone is white needle-like crystal at room temperature, naturally occurring in the stems and leaves of Artemisia scoparia, in the roots of plants such as ginseng baby Vine. It can be used in the manufacture of choleretic drugs and other raw materials for organic synthesis.

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