4-Chlorobenzoyl chloride p Chlorobenzoyl chloride | CAS 122 01 0

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High purity 4-Chlorobenzoyl chloride for pharmaceutical intermediates, agrochemical synthesis, and specialty organic reactions.

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Specification

Purity by GC: 98.0 percent minimum, typical batch 98.5 to 99.0 percent
Appearance: Colorless to pale yellow clear liquid (low melting solid at room temperature)
Molecular formula: C7H4Cl2O
Molecular weight: 175.01 g per mol
Melting point: 11 to 14 degrees Celsius
Boiling point: 102 to 104 degrees Celsius at 11 mmHg
Density: 1.365 to 1.377 g per mL at 20 degrees Celsius
Refractive index: 1.576 to 1.580 at 20 degrees Celsius
Flash point: 105 degrees Celsius (closed cup)
Water solubility: Reacts with water
Vapor pressure: 0.1 plus minus 0.4 mmHg at 25 degrees Celsius
LogP: 2.52 at 25 degrees Celsius
Stock Status: In Stock in US warehouse and China hub

Available Quantity and Lead Time

Regular supply: 500 g to 25 metric tons per shipment
Lead time: 3 to 5 days for standard packaging; bulk orders require 7 to 10 days

Document Support

COA SDS HPLC chromatogram NMR spectrum Mass spectrum MS available upon request

Application

4-Chlorobenzoyl chloride is a highly reactive acyl chloride and a versatile building block widely utilized in pharmaceutical, agrochemical, and specialty chemical industries.

In pharmaceutical synthesis, it serves as a key intermediate for the production of various active pharmaceutical ingredients, including anti inflammatory drugs such as indomethacin and other non steroidal anti inflammatory agents. It facilitates the introduction of chlorobenzoyl groups into drug molecules, enhancing the development of medications.

In agrochemical manufacturing, 4-chlorobenzoyl chloride is an important intermediate for the synthesis of fungicides such as dimethomorph, insecticides including flumethrin, rodenticides like coumachlor and warfarin, and other crop protection agents.

In organic synthesis, this compound is commonly used as a reagent for the synthesis of esters, ethers, and amide compounds. It serves as a promoter in the synthesis of alpha aminonitriles, as a derivatization agent, and as a self assembling dipole molecule to improve hole injection in conjugated polymers. It is also employed in Friedel Crafts acylation reactions for the preparation of various aromatic ketones.

In biochemical research, 4-chlorobenzoyl chloride is used to synthesize 4-chlorobenzoyl CoA by reacting with CoA in KHCO3 buffer. It also finds applications in dye manufacturing and the production of peroxides.

Custom Synthesis Support

We offer custom synthesis for 4-chlorobenzoyl chloride derivatives including isotopically labeled analogs and higher purity grades (99.5 percent and above). Custom packaging under inert atmosphere is available. Share your technical datasheet for feasibility review.

Packaging and Shipping

Available in 100 g, 500 g, 1 kg, 5 kg, 25 kg, or 200 kg steel drums with PTFE lined closures. Custom packaging such as amber glass bottles with PTFE lined caps under nitrogen is supported. Fastest dispatch within 7 days after order confirmation.

4-Chlorobenzoyl chloride is a corrosive liquid, UN 3265, Class 8, Packing Group II. Store below 30 degrees Celsius in a cool, dry, well ventilated area away from strong oxidizing agents, water, moisture, alcohol, and bases. Keep container tightly sealed. The compound is moisture sensitive and reacts with water and alcohol. Handle under dry conditions with appropriate personal protective equipment.

Why XinChem

XinChem provides 4-chlorobenzoyl chloride with strict control of purity and impurity profile for US customers. Our ISO 9001 certified facility monitors every batch by GC and titration analysis, ensuring consistent quality for pharmaceutical and agrochemical applications. We maintain a buffer stock in US warehouses for emergency deliveries within 48 hours. Each order includes a full documentation package: COA, SDS, and chromatograms accessible through our online portal. Our technical support team assists with handling under anhydrous conditions, stability optimization, and regulatory compliance including TSCA (listed), EINECS 204-515-3, and REACH registration. For contract customers, we offer quarterly price locks and consignment inventory to reduce supply chain risk. Trusted by numerous pharmaceutical, agrochemical, and specialty chemical companies in North America. We also provide free sample evaluation for qualified R&D projects and a price match guarantee against any valid competitor quote for equivalent quality. All shipments include clear handling instructions and appropriate hazard communication to ensure safety throughout the supply chain.

FAQ

Q1 How should 4-chlorobenzoyl chloride be stored safely?
A Store below 30 degrees Celsius in a cool, dry, well ventilated area away from strong oxidizing agents, water, moisture, alcohol, and bases. Keep container tightly sealed. The compound is moisture sensitive and reacts with water and alcohol. Shelf life is 24 months under recommended conditions.

Q2 What purity grades do you supply?
A Standard grade is 98.0 percent minimum by GC and titration. We also supply 99.0 percent and 99.5 percent grades for pharmaceutical and analytical reference applications.

Q3 Is 4-chlorobenzoyl chloride soluble in water?
A No, it reacts with water and alcohol. It is soluble in organic solvents such as methylene chloride, ether, chloroform, DMSO, and benzene.

Q4 Do you provide sample quantities for method development?
A Yes, free samples of 100 g are available for qualified US companies. Shipping fee applies for small quantities due to hazardous material classification.

Q5 What safety precautions are required when handling 4-chlorobenzoyl chloride?
A 4-Chlorobenzoyl chloride is corrosive and causes severe skin burns and eye damage. May cause respiratory irritation. Use in a fume hood with full PPE including chemical resistant gloves, safety goggles, and face shield. Do not breathe vapors. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. For spills, neutralize with appropriate agents and dispose according to local regulations.

Q6 What are the main applications of 4-chlorobenzoyl chloride?
A Primary applications include: (1) pharmaceutical intermediates for anti inflammatory drugs such as indomethacin; (2) agrochemical intermediates for fungicides (dimethomorph), insecticides (flumethrin), and rodenticides; (3) organic synthesis reagent for esters, ethers, and amides; (4) Friedel Crafts acylation reactions; (5) biochemical research for CoA derivative synthesis; and (6) dye manufacturing.

Q7 Is 4-chlorobenzoyl chloride listed on TSCA and REACH?
A Yes, it is listed on the TSCA inventory and has REACH registration. EINECS number is 204-515-3. Please request our regulatory package for your specific application and compliance documentation.