4-Chloro-6-(trifluoromethyl)pyrimidine（CAS# 37552-81-1)
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. |
Introduction
4-Chloro-6-(trifluoromethyl)pyrimidine is an organic compound with the chemical formula C5H2ClF3N2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-Chloro-6-(trifluoromethyl)pyrimidine is a colorless or pale yellow crystalline solid.
-Solubility: It is soluble in many organic solvents, such as ethanol, dimethylformamide, etc.
-Melting point: Its melting point is about 69-71 degrees Celsius.
-Stability: 4-Chloro-6-(trifluoromethyl)pyrimidine is relatively stable at room temperature.
Use:
-Chemical synthesis: 4-Chloro-6-(trifluoromethyl)pyrimidine is an important intermediate, often used in organic synthesis reactions. It can be used as a key intermediate in the synthesis of heterocyclic nucleophiles, copper catalysts and bifunctional compounds.
-Pesticide: This compound can also be used in the manufacture of pesticides to inhibit the growth and reproduction of pests or weeds.
Preparation Method:
- 4-Chloro-6-(trifluoromethyl)pyrimidine is prepared by many methods, one of which is obtained by the reaction of 4-chloro-6-aminopyrimidine and trifluoromethyl borate. The specific reaction conditions and processes will vary slightly according to the reports of different researchers.
Safety Information:
- 4-Chloro-6-(trifluoromethyl)pyrimidine has limited toxicity information, but it is generally considered to be less harmful to humans and the environment.
-When handling this compound, care should be taken to avoid inhalation of dust, contact with skin and eyes, and maintain good ventilation.
-When using or processing the compound, follow relevant safety procedures and wear appropriate personal protective equipment (such as gloves, protective glasses and protective clothing).
-If inhaled or exposed to the compound, seek medical attention immediately and bring a container or label for your doctor’s reference.
