4-Bromo-3-nitrobenzoic acid（CAS# 6319-40-0)
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R22 – Harmful if swallowed |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Note | Irritant |
Introduction
3-nitro-4-bromobenzoic acid is an organic compound with the formula C7H4BrNO4.
Nature:
-Appearance: Colorless crystal or light yellow crystalline powder.
-melting point: 215-218 ℃.
-Solubility: Solubility in water is small, soluble in ethanol, ether and chloroform and other organic solvents.
Use:
3-nitro-4-bromobenzoic acid is an important organic synthesis intermediate, which is widely used in pharmaceutical synthesis and dye industry.
-Drug synthesis: can be used as a precursor for the synthesis of some non-steroidal anti-inflammatory drugs and other drugs.
-Dye industry: can be used for synthetic dyes and pigments.
Preparation Method:
3-nitro-4-bromobenzoic acid can be prepared by nitration of 4-bromobenzoic acid. The specific steps are as follows:
1. Dissolve 4-bromobenzoic acid in a mixed solution of nitric acid and glacial acetic acid.
2. Stir the reaction mixture at low temperature.
3. The product precipitated in the reaction mixture is filtered and washed, and then dried to obtain 3-nitro-4-bromobenzoic acid.
Safety Information:
3-nitro-4-bromobenzoic acid has a stimulating effect on the skin and eyes, and should be fully cleaned after contact. During use and storage, avoid inhaling its dust and wear protective equipment if necessary. In addition, 3-nitro-4-bromobenzoic acid may also cause harm to the environment, so care should be taken to comply with relevant environmental safety regulations.
