4-amino-3-(trifluoromethyl)benzonitrile（CAS# 327-74-2)
| Risk Codes | R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed. R36/38 – Irritating to eyes and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3439 |
| Hazard Note | Toxic/Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
It is an organic compound with the chemical formula C8H5F3N2. The following are some properties, uses, preparation and safety information about the compound:
Nature:
-Appearance: Colorless crystalline solid.
-Melting point: About 151-154°C.
-Boiling point: approximately 305°C.
-Solubility: It is relatively soluble in polar solvents such as ethanol, chloroform and dimethyl sulfoxide.
Use:
-is used as an intermediate in organic synthesis for the synthesis of related compounds.
-It is also used as a synthetic raw material for anti-cancer drugs and pesticides in the pharmaceutical field.
Method:
It can be synthesized by the following steps:
1. 3-cyano-4-trifluoromethylbenzenetonitrile is reacted with aminobenzene under alkaline conditions.
2. After proper purification and crystallization treatment, the target product is obtained.
Safety Information:
-Avoid contact with oxidants, strong acids and strong bases during storage and handling.
-This compound may release toxic gases when heated and burned.
-Wear appropriate personal protective equipment such as goggles and gloves when using.
