4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile（CAS# 189956-45-4)

Molecular Formula	C11H8N4O
Molar Mass	212.21
Density	1.31±0.1 g/cm3(Predicted)
Melting Point	>300°C
Boling Point	399.7°C at 760 mmHg
Flash Point	195.6°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0-0Pa at 20-25℃
Appearance	Solid
Color	Pale Brown to Brown
pKa	8.66±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.67

Product Detail

LogP	0.9 at pH6.6
use	4-[(4-hydroxy-2-pyrimidinyl) amino] benzonitrile can be used as an intermediate in organic synthesis and a pharmaceutical intermediate, and can be used in the laboratory Organic synthesis process and chemical and pharmaceutical research and development process.
preparation	weigh 2-(methylthio) pyrimidine -4(3H)-one (3g,21mmol) and 4-aminobenzonitrile (2.99g,25mmol) in a 50mL round bottom flask, protected by nitrogen, slowly heated to 180 ℃, and reacted for 8 hours. After the reaction is cooled, 20mL of acetonitrile is added for ultrasonic treatment, filtration, the filter cake is washed with acetonitrile, no 4-aminobenzonitrile residue is detected by TLC, and the light yellow solid obtained by drying the filter cake is 4-((4-oxo -1, 6-dihydropyrimidine -2-yl) amino) benzonitrile with a yield of 73.6%.