3-Trifluoromethylpyridine（CAS# 3796-23-4)
| Risk Codes | R10 – Flammable R25 – Toxic if swallowed R36/37/38 – Irritating to eyes, respiratory system and skin. R11 – Highly Flammable |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37 – Wear suitable gloves. S36 – Wear suitable protective clothing. |
| UN IDs | UN 1992 3/PG 3 |
| WGK Germany | 2 |
| Hazard Note | Irritant |
| Hazard Class | 3 |
| Packing Group | II |
Introduction
3-(trifluoromethyl)pyridine, also known as 1-(trifluoromethyl)pyridine, is an organic compound.
Quality:
3-(trifluoromethyl)pyridine is a colorless liquid with a strong odor. It is soluble in many organic solvents such as ethanol, dimethylformamide, and dimethyl sulfoxide.
Use:
3-(trifluoromethyl)pyridine is widely used as catalysts, solvents and reagents in organic synthesis. It can be used as a boron chloride reagent in the synthesis of alcohols, acids, and ester derivatives. It can also be used as a sodium hydroxide-catalyzed borate esterification reagent for aldehydes and ketones.
Method:
There are several ways to prepare 3-(trifluoromethyl)pyridine. A common method is to obtain the product by the reaction of pyridine and trifluoromethylsulfonyl fluoride. The pyridine was dissolved in an ether solvent, and then trifluoromethylsulfonyl fluoride was slowly added dropwise. Reactions are usually carried out at low temperatures and require adequate ventilation to avoid the spread of toxic gases.
Safety Information: It is a flammable liquid that can easily cause fire when exposed to an open flame or high temperature. It is also an organic solvent that may have an irritating effect on the skin, eyes, and respiratory system. Protective gloves, goggles, and breathing apparatus should be worn during operation, and the operation should be carried out in a well-ventilated area.
