3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine(CAS#956010-87-0)

 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine(CAS#956010-87-0)

Uses: It is an important intermediate in organic synthesis. In the field of medicinal chemistry, it can be used to synthesize compounds with potential biological activity, and trifluoromethyl and pyrazolopyridine rings in their structures can be modified by various chemical reactions, so as to introduce different pharmacophores to obtain drug molecules with specific pharmacological effects, which may have antibacterial, antiviral, antitumor and other activities. In materials science, it is also possible to prepare organic materials with special properties, such as optoelectronic materials, through further derivatization reactions.
Synthesis method: It has been reported in the literature that 2-fluoropyridine was used as the starting material for the synthesis of multiple grams in one pot by directional ortho-metallization (DOM) technology. This method takes advantage of the special structure of 2-fluoropyridine to introduce trifluoromethyl and construct pyrazolopyridine ring through a series of reactions to obtain the target product. However, the specific synthesis route may vary depending on the raw material and reaction conditions.