3-Chlorothiophene-2-carboxylic acid（CAS# 59337-89-2)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Note | Irritant |
Introduction
3-chlorothiophene-2-carboxylic acid is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:
Quality:
Appearance: 3-chlorothiophene-2-carboxylic acid is a white crystalline solid.
Solubility: It has a certain solubility and can be soluble in some organic solvents such as methylene chloride, methanol and dimethyl sulfoxide.
Chemical properties: As a compound containing thiophene rings and carboxylic acid groups, 3-chlorothiophene-2-carboxylic acid can participate in a variety of organic synthesis reactions.
Use:
3-Chlorothiophene-2-carboxylic acid has a wide range of uses in the chemical industry.
Transfection reagent: Can be used as a transfection reagent for introducing DNA or RNA into cells in molecular biology experiments.
Electrochemical materials: 3-chlorothiophene-2-carboxylic acid and its derivatives can be used to prepare electrochemical materials, such as polythiophene, etc.
Method:
There are many preparation methods for 3-chlorothiophene-2-carboxylic acid, and one of the commonly used methods is as follows:
3-chlorothiophene was reacted with beryllium chloride (BeCl2) in dichloromethane to give 3-chlorothiophene-2-oxalate. It is then hydrolyzed with an alkaline hydrolytic agent such as sodium hydroxide to give 3-chlorothiophene-2-carboxylic acid.
Safety Information:
3-Chlorothiophene-2-carboxylic acid generally carries a low risk under normal conditions of use. As a chemical, the following safety measures should be noted:
Contact protection: Wear protective gloves, safety glasses, and appropriate protective clothing when exposed to 3-chlorothiophene-2-carboxylic acid.
Inhalation protection: Good ventilation should be ensured during operation to prevent inhalation of its dust or vapors.
Storage and handling: 3-chlorothiophene-2-carboxylic acid should be stored in a sealed container to avoid fire and high temperatures.
