3-Chloroisoquinoline(CAS#19493-45-9)
| Hazard Symbols | Xi – Irritant |
| Hazard Note | Irritant |
Introduction
3-Chloroisoquinoline(3-Chloroisoquinoline) is an organic compound with the chemical formula C9H6ClN. The following is a brief description of the nature, use, preparation and safety information of 3-Chloroisoquinoline:
Nature:
-Appearance: 3-Chloroisoquinoline is a white to light yellow crystal or crystalline powder.
-Solubility: 3-Chloroisoquinoline is soluble in Ketone solvents, ether and dichloromethane, and slightly soluble in alcohol solvents.
-Melting point: about 48-50 ℃.
-Spectroscopic data: The nuclear magnetic resonance hydrogen spectrum (NMR) and infrared spectrum (IR) of 3-Chloroisoquinoline can provide characteristic information for its structure.
Use:
-as an intermediate: 3-Chloroisoquinoline can be used for the synthesis of a variety of pharmaceutical and pesticide intermediates, such as for the synthesis of anti-epileptic drugs, antidepressants, anticancer drugs and pesticides.
Method:
-o-dinitro aromatic compound method: 3-Chloroisoquinoline is prepared by nitration and chlorination of O-diamino aromatic compounds.
-imidazole base method: the imidazole base is reacted with substituted acetophenone, and then cyclization reaction is carried out to obtain 3-Chloroisoquinoline.
Safety Information:
-Toxicity: 3-Chloroisoquinoline may cause damage to the human body when exposed or ingested in large quantities, and has certain toxicity. Care should be taken to avoid inhalation, ingestion or skin contact.
-flammability: 3-Chloroisoquinoline is a combustible substance, which may cause combustion or explosion in case of fire source, so it should be kept away from open flame and high temperature.
-Environmental impact: 3-Chloroisoquinoline has a certain environmental impact, and waste materials should be properly disposed of in accordance with regulations.
