3-CHLORO-4-METHYLPYRIDINE（CAS# 72093-04-0)
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R41 – Risk of serious damage to eyes R37/38 – Irritating to respiratory system and skin. R22 – Harmful if swallowed |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S39 – Wear eye / face protection. |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| Hazard Class | IRRITANT, IRRITANT-H |
Introduction
3-Chloro-4-methylpyridine is an organic compound. Its properties are as follows:
1. Appearance: 3-chloro-4-methylpyridine is a colorless to light yellow liquid.
2. Density: 1.119 g/cm³
4. Solubility: 3-chloro-4-methylpyridine is soluble in most organic solvents and insoluble in water.
The main uses of 3-chloro-4-methylpyridine are as follows:
1. Synthesis of transition metal complexes: It is an important intermediate used in coordination chemistry for the synthesis of amino alcohols, amino alkates, and other nitrogen heterocyclic compounds.
2. Pesticide intermediates: 3-chloro-4-methylpyridine can be used as an intermediate in some insecticides and herbicides.
The method for preparing 3-chloro-4-methylpyridine usually includes the following steps:
1. Nitroation reaction of pyridine: pyridine is reacted with concentrated nitric acid and sulfuric acid to obtain 3-nitropyridine.
2. Reduction reaction: 3-nitropyridine is reacted with an excess of sulfoxide and reducing agent (such as zinc powder) to obtain 3-aminopyridine.
3. Chlorination reaction: 3-aminopyridine is reacted with thionyl chloride to obtain 3-chloro-4-methylpyridine.
The relevant safety information of 3-chloro-4-methylpyridine is as follows:
1. Sensitization: May have an allergenic reaction to certain populations.
2. Irritation: May have an irritating effect on the eyes, respiratory system and skin.
3. Toxicity: It is toxic to human health and must follow proper safety operating procedures.
4. Storage: It should be stored in an airtight container, away from ignition and oxidants, and away from contact with air.
When using 3-chloro-4-methylpyridine, follow relevant safety protocols such as wearing protective eyewear, gloves and protective clothing, and ensure that it is operated in a well-ventilated area. In case of accidental contact or inhalation, seek medical attention immediately and show the product’s Safety Data Sheet to your doctor.
