3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE （CAS# 76041-71-9)

Introduction

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:

1. Nature:

- Appearance: 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine is a colorless to pale yellow solid.

- Solubility: It is almost insoluble in water, but soluble in organic solvents such as ether, methanol and methylene chloride.

- Chemical properties: It is an alkaline compound that performs a neutralizing reaction against acids. It can also be used as a fluorinating reagent to introduce trifluoromethyl groups into other organic compounds.

2. Usage:

- 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine is commonly used in organic synthesis reactions as a catalyst or reagent. For example, it can be used to construct carbon-fluorine bonds and amination reactions.

- It can also be used as a starting material or intermediate in pesticide synthesis.

3. Method:

- A commonly used preparation method is to react pyridine with trifluoroformic acid and sulfuric acid to produce 3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine.

4. Safety Information:

- 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine should be avoided during storage and use in contact with strong oxidants and combustibles to avoid fire or explosion.

- It may have an irritating effect on the skin, eyes, and respiratory tract, and appropriate protective equipment such as gloves, goggles, and respiratory protective equipment should be worn when operating.

- When using or handling the compound, it should be done in a well-ventilated area and avoid inhalation or accidental ingestion. After treatment, the contaminated area should be thoroughly cleaned.