3-Bromo -5-iodobenzoic acid（CAS# 188815-32-9)
Risk and Safety
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29163990 |
3-Bromo -5-iodobenzoic acid（CAS# 188815-32-9) Introduction
-Appearance: 3-Bromo-5-iodobenzoic acid is a white or pale yellow crystalline solid.
-Solubility: It can be partially dissolved in solvents, such as alcohols and ketones, but its solubility in water is low.
-Melting point: It has a higher melting point, usually between 120-125°C.
-Chemical properties: 3-Bromo-5-iodobenzoic acid is a weak acid that can generate corresponding salts under alkaline conditions.
Use:
3-Bromo-5-iodobenzoic acid is mainly used in organic synthesis, especially as an intermediate in drug synthesis. It can be used to synthesize antimalarial drugs such as chloroquine. In addition, it can be used in the synthesis of other organic compounds such as dyes and pesticides.
Method:
3-Bromo-5-iodobenzoic acid can be prepared by chloroalkylation. First, the chloro compound is generated by the reaction of O-iodobenzoic acid and copper bromide, and then it is converted to 3-Bromo-5-iodobenzoic acid by bromination.
Safety Information:
3-Bromo-5-iodobenzoic acid is generally relatively safe under normal conditions of use. However, as a chemical, it is still dangerous. Contact with skin and eyes may cause irritation and burns. Therefore, wear appropriate protective equipment such as gloves and goggles during use. At the same time, avoid inhaling its dust or solution. In the process of storage and handling, it needs to be properly managed to avoid storage with flammable substances, oxidants and other substances. In case of accidental leakage, appropriate measures shall be taken to clean up and deal with it. In the handling of such chemicals, should follow the appropriate safety procedures and guidance.
