3-BROMO-4-METHOXY-PYRIDINE（CAS# 82257-09-8)
| Hazard Symbols | Xn – Harmful |
| Risk Codes | R22 – Harmful if swallowed R37/38 – Irritating to respiratory system and skin. R41 – Risk of serious damage to eyes |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 – Wear eye / face protection. |
Introduction
3-bromo-4-methoxypyridine is an organic compound with a chemical formula of C6H6BrNO and a molecular weight of 188.03. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: 3-bromo-4-methoxypyridine is a light yellow to yellow solid.
2. solubility: soluble in organic solvents such as ether and chlorinated hydrocarbons, insoluble in water.
3. melting point: about 50-53 ℃.
4. density: about 1.54 g/cm.
Use:
3-bromo-4-methoxypyridine is an important organic synthesis intermediate, commonly used in the synthesis of pesticides, pharmaceuticals and other organic compounds. It has a wide range of applications in the field of chemical research and medicine.
Preparation Method:
3-bromo-4-methoxypyridine is generally synthesized by the following steps:
1. 2-bromo-5-nitropyridine is reacted with methanol to obtain 2-methoxy-5-nitropyridine.
2. 2-methoxy-5-nitropyridine reacts with cuprous bromide prepared with sulfuric acid to obtain 3-bromo-4-methoxypyridine.
Safety Information:
1. 3-bromo-4-methoxypyridine is irritating and should avoid contact with skin, eyes and respiratory tract.
2. in handling and use, should wear appropriate personal protective equipment, such as gloves and protective glasses.
3. Storage should prevent contact with oxidants and strong acids, and keep the container sealed.
4. Under reasonable use and storage conditions, 3-bromo-4-methoxypyridine is a relatively safe chemical substance, but it still needs to be operated with caution.
