3-Bromo-2-chlorobenzotrifluoride（CAS# 56131-47-6)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. |
| Hazard Note | Irritant |
Introduction
It is an organic compound with the formula C7H3BrClF3. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: colorless liquid
-Melting point:-14°C
-Boiling point: 162°C
-Density: 1.81g/cm³
-Soluble: Soluble in organic solvents such as ether and dichloromethane, slightly soluble in water
Use:
-is widely used as an intermediate in organic synthesis, especially in the pharmaceutical and pesticide fields.
-It can also be used as a complex in asymmetric synthesis, catalysts and liquid crystals.
Preparation Method:
Synthesized by the following reaction:
1. First, 2-chlorotrifluorotoluene (C7H4ClF3) is reacted with sodium nitrite-N-acetamide complex to obtain 2-nitrotrifluorotoluene (C7H3NO2F3).
2. 2-Nitrotrifluorotoluene reacts with hydrogen bromide, and then the nitro functional group is replaced with the bromine functional group through a substitution reaction to get the nitro functional group.
Safety Information:
-must be an organic compound, which has certain sensitization and toxicity. Please pay attention to correct operation and storage.
-Use should wear protective gloves, goggles and protective masks to avoid contact with skin and inhalation of gas.
-Avoid contact with strong oxidants, strong acids, strong alkalis and fire sources to prevent dangerous reactions.
-Work in a well-ventilated place, away from fire and heat sources.
-In case of contact or ingestion, seek medical attention immediately.
