3-Bromo-2-chloro-5-(trifluoromethyl)pyridine（CAS# 71701-92-3)
Risk and Safety
| Risk Codes | R25 – Toxic if swallowed R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S7/9 - S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 – Wear suitable protective clothing and gloves. S38 – In case of insufficient ventilation, wear suitable respiratory equipment. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S51 – Use only in well ventilated areas. |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
Introduction
The compound has important applications in drug synthesis and pesticide synthesis. It can be used as an intermediate for the synthesis of biologically active compounds. For example, it can be used to synthesize antiviral drugs and pesticides, etc.
The 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine can be prepared by different methods. A common method is to introduce bromine and chlorine atoms in the reaction by bromination and chlorination, respectively, starting with pyridine. Then, a trifluoromethyl group is introduced in a trifluoromethylation reaction. This synthesis is usually carried out under an inert atmosphere to ensure high selectivity and yield of the reaction.
The 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine has limited safety information. It may be irritating to the eyes, respiratory system and skin. During use, care should be taken to avoid direct contact with skin and eyes. At the same time, appropriate protective measures should be taken during operation, such as wearing protective glasses, gloves and protective clothing.
In addition, during handling and storage, care should be taken to prevent contact with flammable materials and maintain good ventilation. When disposing of waste, local regulations should be followed and appropriate waste disposal methods should be adopted. It is best used and handled under the guidance of experienced chemists.
