2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid(CAS#847943-29-7)
2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid
（847943-29-7），Synthesis method
In general, 2- and 5-position chiral centers can be constructed by using a suitable pyrrolidine derivative as a starting material, using methods such as chiral induction or chiral resolution.
For example, pyrrolidine with a suitable substituent is used as a substrate, the amino group is first protected, the tert-butoxycarbonyl group is introduced, then the ethyl group is introduced at position 5 through a suitable alkylation reaction, and then the carboxyl group is introduced at position 2 through appropriate oxidation or other reaction steps, and finally the target product is obtained through a series of separation and purification steps.
Fields of application
Drug synthesis intermediates: (2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid is an important intermediate in the synthesis of many drugs. It can be used as a key building block for the construction of specific bioactive molecules, and by reacting with other organic molecules, different functional groups or structural fragments are introduced, so as to synthesize compounds with potential medicinal value. For example, it may be used in the synthesis of some antimicrobial drugs and neuroactive drugs.
Chiral ligand synthesis: Due to its chiral structure, it can be used to synthesize chiral ligands. Chiral ligands play an important role in asymmetric catalytic reactions, which can selectively catalyze chemical reactions and make the reaction proceed in the direction of generating specific chiral products, which is of great significance in the field of organic synthetic chemistry.
Storage conditions
It should be stored in a cool, dry and well-ventilated warehouse, away from fire and heat sources.
Avoid contact with oxidants, acids and alkalis and other substances to prevent chemical reactions.
It is recommended to store under the protection of an inert gas to prevent it from oxidizing or other deterioration reactions, and can generally be stored in an inert gas environment such as nitrogen or argon.
