2-Methylsulfonyl-4-trifluoromethylbenzoic Acid (CAS# 142994-06-7)

2-Methylsulfonyl-4-trifluoromethylbenzoic Acid (CAS# 142994-06-7) introduction

2-methylsulfonyl-4-trifluoromethylbenzoic acid (MSTFA) is an organic compound with the following properties:

Appearance: MSTFA is a colorless to light yellow liquid.

Solubility: It is soluble in most organic solvents, such as dimethylformamide, acetonitrile, and methanol.

Stability: MSTFA is a relatively stable compound, but it may decompose and produce toxic gases or corrosive substances during storage or heating.

MSTFA is mainly used for analyzing derivatization reactions in chemistry, with specific applications including:

In gas chromatography-mass spectrometry (GC-MS) analysis, MSTFA is used as a derivative reagent for sample pretreatment, which can convert non-volatile compounds into easily analyzable derivatives.

MSTFA can be used for the derivatization of lipids, bioactive substances (such as ketones and amino acids), and compounds with active hydrogens (such as aldehydes, ketones, and acids).

A common method for preparing MSTFA is to react 2-methylsulfonyl-4-trifluoromethylphenylcarboxylic acid (MSTAA) with fluorinated sulfoxide (SO2F2) or DAST (difluorothioamide trifluoromethanesulfonyl chloride).

MSTFA safety information: It may produce toxic gases or corrosive substances, and the following safety measures should be followed:

Avoid contact with skin, eyes, or respiratory tract, and wear appropriate protective equipment such as gloves, goggles, and respirators when using.

Operate in a well ventilated area and avoid inhaling its vapors or dust.

When storing, keep away from sources of fire and incompatible materials.

Waste disposal should comply with local regulations and should not be dumped indiscriminately.