2-Fluoropyridine-5-carboxaldehyde（CAS# 677728-92-6)
| Hazard Symbols | Xi – Irritant |
| UN IDs | 1993 |
| Hazard Note | Irritant |
| Hazard Class | 3 |
| Packing Group | Ⅲ |
Introduction
It is an organic compound with the molecular formula C6H4FN, which is structurally substituted by the 5-formaldehyde group on the 2-fluoropyridine ring. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless or light yellow liquid.
-Solubility: Soluble in most organic solvents, such as ethanol, acetone, etc.
-Melting point: about -5°C.
-Boiling point: about 135 ℃.
-Specific gravity: about 1.214g/cm³.
-Content: Purity is usually above 95%.
Use:
-is useful as a starting material or intermediate in organic synthesis.
-It is commonly used in the pharmaceutical field to prepare drugs, such as antipsychotics and antineoplastic drugs.
-The compound can also be used to prepare pesticides, sensitizers, dyes, etc.
Preparation Method:
There are two main preparation methods:
1. pyridine and cyanide iodine reaction, and then the fluorination reaction, and finally add formaldehyde product.
2. pyridine reacts with methane and boron trifluoride to form 2-methylpyridine, then fluorination reaction is carried out, and formaldehyde is added to obtain pyridine.
Safety Information:
-A certain degree of irritation and corrosiveness, should avoid contact with skin, eyes and respiratory tract.
-Follow relevant safety procedures during use and storage.
-Use in a well-ventilated area and wear appropriate protective equipment, such as gloves, goggles and protective clothing.
-In case of contact, rinse immediately with plenty of water and seek medical attention.
-Liquid and waste should be disposed of in accordance with local regulations.
