2-Fluorobenzonitrile（CAS# 394-47-8)
Risk and Safety
| Risk Codes | R22 – Harmful if swallowed R37/38 – Irritating to respiratory system and skin. R41 – Risk of serious damage to eyes R36/37/38 – Irritating to eyes, respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 – Wear eye / face protection. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S36 – Wear suitable protective clothing. |
2-Fluorobenzonitrile（CAS# 394-47-8) Introduction
2-Fluorobenzonitrile is an organic compound. It is a colorless to pale yellow liquid with a strong aroma. The following is an introduction to the properties, uses, preparation methods and safety information of 2-fluorobenzonitrile:
Properties:
- 2-Fluorobenzonitrile is a liquid that is immiscible in water and has a low vapor pressure at room temperature.
- It has good solubility and can be dissolved in many organic solvents such as ethanol, acetone and dimethylformamide.
- It is stable in air, but dangerous chemical reactions may occur when heated to high temperatures or in contact with strong oxidants.
Uses:
- It can also be used as a raw material for coatings, dyes and fragrances.
Preparation method:
- There are two main methods for the preparation of 2-fluorobenzonitrile: cyanide substitution method and fluoride substitution method.
- The cyanide substitution method refers to the substitution of the cyano group to the benzene ring and then the introduction of fluorine atoms to replace the cyano group.
- Fluoride substitution method refers to the use of fluoride as a raw material, reacting with chlorine, bromine or haloform on the benzene ring, replacing chlorine, bromine or haloform with fluorine to obtain 2-fluorobenzonitrile.
Safety Information:
- 2-Fluorobenzonitrile is toxic to the human body. Please avoid direct contact with the skin, eyes and inhalation of its vapor.
- Wear appropriate personal protective equipment such as gloves, safety glasses and protective clothing during operation.
- When storing, 2-fluorobenzonitrile should be placed in a sealed container, away from fire and oxidants, and properly stored to avoid leakage and impact.
