2-Cyano-4-methylpyridine（CAS# 1620-76-4)
Risk and Safety
| Hazard Symbols | Xi – Irritant |
| Risk Codes | R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R41 – Risk of serious damage to eyes R37/38 – Irritating to respiratory system and skin. R22 – Harmful if swallowed R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 – Do not breathe dust. S36/37 – Wear suitable protective clothing and gloves. S39 – Wear eye / face protection. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. |
| UN IDs | 3276 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | 6.1 |
| Packing Group | III |
2-Cyano-4-methylpyridine（CAS# 1620-76-4) Information
| Application | 2-cyano-4-methylpyridine is an organic intermediate, which can be first oxidized from 4-methylpyridine to prepare 4-Methyl-pyridine-N-oxide, and then substituted with cyano group to obtain. 4-methyl-pyridine-N-oxide can be used to prepare 4-methyl -2, 6-dicarboxypyridine, 4-methyl -2, 6-dicarboxypyridine is a very useful pyridine derivative and a very important intermediate compound, which is widely used in the field of pharmacy. |
| preparation | 4-methyl-pyridine-N-oxide (0.109g,1mmol), trimethylcyanosilane (0.119g,1.2mmol),H-diethyl phosphite (0.276g,2mmol), carbon tetrachloride (0.308g,2mmol), triethylamine (0.202g,2mmol) and acetonitrile 10mL in a 50mL three-mouth flask, react at room temperature for 6h. After the reaction is completed, the solvent is removed under reduced pressure and separated by column chromatography (petroleum ether/ethyl acetate, V/V = 4:1) to obtain colorless liquid target compound with 80% yield. |
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