2-Chloro-6-methoxy-3-nitropyridine（CAS# 38533-61-8)
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R44 – Risk of explosion if heated under confinement R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 – Wear suitable gloves and eye/face protection S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
Introduction
It is an organic compound with the chemical formula C6H5ClN2O3.
Nature:
-Appearance: White to light yellow solid
-Melting Point: 44-46°C
-Boiling point: 262°C
-Soluble in: alcohol and ether, insoluble in water
Use:
is an important intermediate, widely used in the field of organic synthesis. It can be used to synthesize a variety of biologically active compounds, such as drugs, dyes and pesticides.
Preparation Method:
Synthesis can be carried out through the following steps:
1. 2-Nitro-6-formylpyridine was obtained by reacting 2-nitro-6-nitro-pyridine with sulfuric acid.
2. The reaction of 2-nitro-6-formylpyridine and chloromethyl ether under the action of alkali is generated.
3. Purification and crystallization steps were performed to obtain the pure product.
Safety Information:
A hazardous substance that may cause irritation and allergic reactions by exposure or inhalation. When operating, wear appropriate protective measures such as gloves, glasses and protective clothing, and ensure that the operation is carried out in a well-ventilated environment. During storage and handling, contact with strong oxidants and flammable materials should be avoided.
