2-Chloro-5-fluoronicotinic acid（CAS# 38186-88-8)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S7/9 - S24/25 – Avoid contact with skin and eyes. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 – Wear suitable protective clothing and gloves. S38 – In case of insufficient ventilation, wear suitable respiratory equipment. S51 – Use only in well ventilated areas. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
Introduction
2-chloro-5-fluoronicotinic acid. The following is an introduction to the properties, uses, preparation methods and safety information of 2-chloro-5-fluoronicotinic acid:
Quality:
- 2-Chloro-5-fluoronicotinic acid is a colorless crystalline solid.
- At room temperature, it has a lower solubility and less solubility in water.
- It is strongly acidic and can react with alkali to produce the corresponding salt.
- 2-Chloro-5-fluoronicotinic acid is a highly oxidizing substance.
Use:
- 2-Chloro-5-fluoronicotinic acid can be used as a reagent for strong acids as an acid catalyst in organic synthesis reactions.
- It can be used for fluorinated reactions in organic synthesis, such as fluorination and aromatic cyclofluorination.
- 2-Chloro-5-fluoronicotinic acid can also be used as an intermediate in dyes and fluorescent brighteners.
Method:
- A common preparation method for 2-chloro-5-fluoronicotinic acid is by reacting 2,5-diaminoalkynyl niacin with an appropriate amount of hydrofluoric acid and chlorinating agents.
Safety Information:
- 2-chloro-5-fluoronicotinic acid is an organic compound that is irritating and may have irritating effects on the skin, eyes, and respiratory system. Wear an appropriate amount of protective gear when using and avoid direct contact with skin and eyes.
- During operation, ventilation should be strengthened to avoid inhalation of vapors from this compound.
- 2-Chloro-5-fluoronicotinic acid should be kept away from heat sources and combustible substances and stored in a dry, cool place.
