2′-Chloro-4-fluoroacetophenone（CAS# 456-04-2)
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R34 – Causes burns R23/25 – Toxic by inhalation and if swallowed. R36 – Irritating to the eyes |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 – After contact with skin, wash immediately with plenty of soap-suds. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S27 – Take off immediately all contaminated clothing. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | AM6550000 |
| FLUKA BRAND F CODES | 9-19 |
| HS Code | 29147000 |
| Hazard Note | Corrosive/Lachrymatory |
| Hazard Class | 8 |
| Packing Group | II |
Introduction
2-Chloro-4′-fluoroacetophenone is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:
Quality:
- Appearance: 2-Chloro-4′-fluoroacetophenone is a colorless to pale yellow liquid.
- Solubility: Soluble in organic solvents such as chloroform, ethanol and ether.
Use:
- Chemical research: 2-chloro-4′-fluoroacetophenone is a commonly used intermediate in organic synthesis and can be used in the synthesis of other organic compounds.
Method:
- There are many preparation methods for 2-chloro-4′-fluoroacetophenone, and one of the commonly used methods is obtained by fluorination of chloroacetophenone. The specific steps include adding hydrofluoric acid and sodium palladium hydroxide catalyst to the reaction solvent to react chloroacetophenone with fluorine gas to generate 2-chloro-4′-fluoroacetophenone.
Safety Information:
- 2-Chloro-4′-fluoroacetophenone is an organic compound, and its potentially harmful properties require careful handling.
- When using or storing, avoid contact with combustible substances, strong oxidizing agents, and strong acids.
- Adequate ventilation should be taken during operation and appropriate personal protective equipment such as gloves and safety goggles should be worn.
