2-Chloro-3,4-dihydroxyacetophenone CAS 99-40-1
Risk and Safety
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 – Wear suitable gloves and eye/face protection S36 – Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29252900 |
99-40-1 - Reference Information
| Overview | 3, 4-dihydroxy-2 ‘-chloroacetophenone is a key intermediate in the synthesis of carbamot. Carbazil also known as blood, adrenal pigment ammonia urea sodium salicylate, mainly used for increased capillary permeability caused by bleeding. |
| Use | The intermediate of haemostatic drug anluoxue, adrenomimetic drug gashaler, etc. |
| production method | add catechol and chloroacetic acid to a dry reaction pot, raise the temperature to 60 °c, and stir, 85-90 degrees C insulation 0.5h. Cool to below 65 ℃, add phosphorus oxychloride, react at 60-70 ℃ for 4h,70-80 ℃ for 4h. When it is difficult to stir the reactants thick, add water, raise the temperature, and hydrolyze at 90-100 ℃ for 0.5h. The crystals were cooled to below 10 ° C., and filtered. The solid matter was washed with water until neutral to obtain 2-chloro-3 ‘,4′-dihydroxyacetophenone. |
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