2-Bromobenzoyl chloride(CAS#7154-66-7)

Introduction

O-bromobenzoyl chloride is also known as 2-bromobenzoyl chloride. The following is an introduction to its nature, use, manufacturing methods and safety information:

Quality:

- Appearance: O-bromobenzoyl chloride is a colorless liquid or a yellowish liquid.

- Solubility: Slightly soluble in water, more soluble in organic solvents such as ether, methanol and methylene chloride.

- Reactivity: O-bromobenzoyl chloride is an acyl chloride compound that is prone to acyl substitution reactions.

Use:

- O-bromobenzoyl chloride is commonly used in acyl chlorination reactions in organic synthesis for the introduction of acyl groups.

- In some organic synthesis, it can be used as a vulcanizing agent, reducing agent or oxidizing agent.

Method:

O-bromobenzoyl chloride is usually prepared by the bromination reaction of o-bromobenzoyl chloride. The specific steps are as follows:

First, o-bromobenzophenone is reacted with bromine under acidic conditions to produce o-bromobenzoic acid.

The o-bromobenzoic acid is then reacted with phosphoryl chloride (POCl₃) to produce o-bromobenzoyl chloride.

Safety Information:

- O-bromobenzoyl chloride is irritating and should be avoided from contact with the skin, eyes and respiratory tract.

- Wear protective gloves, goggles and protective clothing when using.

- Avoid contact with strong oxidizing agents or strong alkalis, which may trigger dangerous reactions.

- Waste and solvents should be properly disposed of during operation and appropriate laboratory safety measures should be taken.