2-Bromo-6-chlorobenzoic acid（CAS# 93224-85-2)

Introduction

2-Bromo-6-chlorobenzoic acid. The following is an introduction to its nature, use, manufacturing method and safety information:

Quality:

- Appearance: Colorless crystalline solid

- Solubility: soluble in organic solvents such as alcohol and ether solvents

- Chemical properties: 2-bromo-6-chlorobenzoic acid is a strong acid that can be neutralized with alkalis. It can also be reduced to its corresponding benzoic acid or benzaldehyde.

Use:

-2-Bromo-6-chlorobenzoic acid can be used in organic synthesis reactions, and is often used as an intermediate in the pharmaceutical industry and pesticide manufacturing.

Method:

-2-Bromo-6-chlorobenzoic acid can be obtained from p-bromobenzoic acid by substitution reaction. The usual preparation method is to react p-bromobenzoic acid with a dilute acid solution, add stannous chloride(II.) as a catalyst, and after an appropriate temperature and reaction time, the target product is obtained.

Safety Information:

-2-Bromo-6-chlorobenzoic acid is an organohalide and should be used with caution.

- Skin contact may cause irritation and redness, so avoid skin contact as much as possible and wear appropriate protective gloves.

- If inhaled or ingested, it may cause harm to the respiratory and digestive systems, so it should be kept away from inhalation and accidental ingestion.

- During operation, good ventilation conditions should be maintained and operation in confined spaces should be avoided.

Application
2-Bromo-6-chlorobenzoic acid (CAS 93224-85-2) is a versatile halogenated benzoic acid that serves as a key building block and intermediate in organic synthesis. Its structure, featuring both bromine and chlorine substituents, enables diverse chemical transformations, including nucleophilic substitution and palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura coupling. In the pharmaceutical industry, this compound is utilized as a critical intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Notably, it is employed in the preparation of Diclofenac Monobromo Sodium Salt Impurity (D436490), an essential reference standard for quality control and analytical method development. It also serves as a precursor for Dapagliflozin, a selective SGLT2 inhibitor for type 2 diabetes mellitus. In agrochemical research, 2-Bromo-6-chlorobenzoic acid is a valuable intermediate for synthesizing herbicides and pesticides, with its structural properties contributing to the efficacy of these crop protection agents. The compound's dual halogenation and carboxylic acid functionality make it a highly adaptable scaffold for constructing complex molecular frameworks in drug discovery, agricultural chemistry, and functional material synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-Bromo-6-chlorobenzoic acid to support your research and production needs. Contact us today for a competitive quote and reliable global supply.