2-Bromo-5-(trifluoromethyl)pyridine（CAS# 50488-42-1)
| Risk Codes | R25 – Toxic if swallowed R36/37/38 – Irritating to eyes, respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S22 – Do not breathe dust. S36 – Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
Introduction
2-Bromo-5-(trifluoromethyl)pyridine (also known as BTFP) is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:
Quality:
- Appearance: White solid
- Molecular weight: 206.00 g/mol
- Solubility: BTFP is easily soluble in organic solvents (e.g., alcohols, ethers, ketones) but less soluble in water.
Use:
- As a synthesis intermediate: BTFP is widely used in the preparation of organic synthesis intermediates, such as pyridine compounds, aromatic compounds, etc.
- As a ligand: BTFP can be used as a ligand for metal complexes and is involved in various catalytic reactions and the preparation of functional materials.
- As a reagent: BTFP plays an important role in organic synthesis, such as coupling reaction, substitution reaction, and reduction reaction.
Method:
2-Bromo-5-(trifluoromethyl)pyridine can be synthesized by the following steps:
1. Dissolve 2-amino-5-(trifluoromethyl)pyridine in a suitable organic solvent, such as alcohol or ketone.
2. Add bromine compounds (e.g. hydrogen bromide, methyl bromide).
3. Perform the reaction at the right temperature and stirring conditions.
4. Filter the product and carry out crystallization and purification.
Safety Information:
- BTFP may solidify or crystallize at low temperatures, please store at room temperature and avoid crystallization.
- Wear appropriate protective gloves and glasses during operation to avoid contact with skin and eyes.
- Avoid inhaling its dust or vapors, as BTFP may have an irritating effect on the respiratory tract.
- Refer to the relevant safety manual when using or handling BTFP, and dispose of waste and solvents appropriately.
