2-AMINO-5-CHLORO-3-PICOLINE（CAS# 20712-16-7)

Risk Codes	R22 – Harmful if swallowed R37/38 – Irritating to respiratory system and skin. R41 – Risk of serious damage to eyes
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - S39 – Wear eye / face protection.
WGK Germany	3
Hazard Class	IRRITANT

It is an organic compound with the chemical formula C7H8ClN. The following is a description of its nature, use, preparation and safety information:Nature:
-Appearance: It is a white crystalline solid.
-Solubility: Its solubility in water is low, but it can be dissolved in organic solvents (such as ethanol and dimethylformamide).
-Stability: It is relatively stable at room temperature and can be decomposed under light or heating conditions.Use:
It has a wide range of applications in the field of organic synthesis.
-It can be used as an intermediate for the synthesis of pyridine compounds and other organic compounds.
-In drug synthesis, it is often used as a synthetic raw material for Antibacterial Drugs and antiparasitic drugs.

Method:
It can be prepared by the following reaction:
-First, 3-picoline reacts with sodium chloride in the presence of sodium carbonate to produce 2-methyl-3-chloropyridine.
-Then, 2-methyl -3-chloropyridine reacts with ammonia in a carbonate buffer solution to generate a pyridine.

Safety Information:
-For the use and operation of chemicals, please refer to the Safety Data Sheet (MSDS) and appropriate operating specifications.
-May be irritating to skin, eyes and respiratory tract.
-When using, avoid inhaling aerosols or contact with skin and eyes.
-In the operation, should follow the appropriate safety measures, such as wearing protective gloves, safety glasses and protective masks.