2-Amino-3 5-dibromo-4-methylpyridine（CAS# 3430-29-3)
| Risk Codes | R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. |
| Hazard Class | IRRITANT |
Introduction
2-Amino-3,5-dibromo-4-methylpyridine is an organic compound.
Quality:
Appearance: White crystalline solid.
Solubility: soluble in organic solvents such as chloroform, ethanol and ether, insoluble in water.
Use:
2-Amino-3,5-dibromo-4-methylpyridine is commonly used as a starting material or reagent for organic synthesis in chemical laboratories. It can be used in the synthesis of pyridine derivatives, imidazole compounds, pyridine imidazole compounds, etc.
Method:
2-Amino-3,5-dibromo-4-methylpyridine can be synthesized by the following steps:
3,5-dibromopyridine and methylpyruvate are reacted under alkaline conditions to form 2-bromo-3,5-dimethylpyridine.
2-Bromo-3,5-dimethylpyridine is reacted with ammonia in chloroform to produce 2-amino-3,5-dimethylpyridine.
2-amino-3,5-dimethylpyridine is reacted with hydrogen bromide to form 2-amino-3,5-dibromo-4-methylpyridine.
Safety Information:
When handling 2-amino-3,5-dibromo-4-methylpyridine, the following safety precautions should be noted:
Avoid inhalation, skin contact, and swallowing. Protective gloves, safety glasses and protective masks should be worn.
It should be used in a well-ventilated area to avoid inhaling its vapors.
It should be kept away from fire, heat and oxidants.
It is strictly forbidden to mix with strong oxidants, reducing agents and strong acids.
It should be stored in a dry, cool, ventilated place, away from fire and heat sources.
