2 5Difluorobenzylbromide（CAS# 85117-99-3)
| Risk Codes | R11 – Highly Flammable R34 – Causes burns R22 – Harmful if swallowed R36 – Irritating to the eyes |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 – Keep away from sources of ignition. |
| UN IDs | UN 2924 3/PG 2 |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Note | Corrosive/Lachrymatory |
| Hazard Class | 8 |
| Packing Group | III |
Introduction
2,5-Difluorobenzyl bromide. The following is an introduction to its nature, use, preparation method and safety information:
Quality:
Appearance: 2,5-benzyl difluorobromide is a colorless or slightly yellow liquid.
Density: 1.74-1.76 g/cm³.
Solubility: Soluble in organic solvents such as alcohols, ethers and non-polar solvents.
Use:
2,5-difluorobenzyl bromide is mainly used as an intermediate and raw material compound in organic synthesis.
In organic synthesis, it is commonly used for fluorination of olefins and selective fluorination of aromatic compounds.
Method:
The preparation of 2,5-difluorobenzyl bromide can be carried out by the following steps:
First, 2,5-dibromobenzyl and trifluoroacetic acid are reacted and refluxed in a gas condensate or water to prepare 2,5-difluorobenzylbromide solution.
The pure 2,5-difluorobenzyl bromide product is then crystallized, filtered, and dried.
Safety Information:
2,5-difluorobenzyl bromide has certain toxicity, and safety precautions should be taken when using it, avoiding contact with skin, eyes and respiratory tract.
During use and preparation, appropriate protective equipment such as laboratory gloves, goggles, and protective masks should be provided.
It should be operated in a well-ventilated area and avoid contact with ignition sources and oxidants.
When storing, 2,5-difluorobenzyl bromide should be kept in a cool, dry and ventilated place, away from fire and combustibles.
Please follow proper laboratory practice and safe handling guidelines when using and handling 2,5-difluorobenzyl bromide.
