2 5-Difluorobromobenzene（CAS# 399-94-0)
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S2637/39 - S37/39 – Wear suitable gloves and eye/face protection |
| UN IDs | UN 2922 |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Note | Flammable |
| Hazard Class | IRRITANT, FLAMMABLE |
Introduction
2,5-Difluorobromobenzene is an organic compound. The following is a detailed introduction to its properties, uses, manufacturing methods and safety information:
Quality:
2,5-Difluorobromobenzene is a colorless liquid with a peculiar odor. It is poorly soluble in water but soluble in organic solvents such as alcohols, ethers, and ketones.
Use:
2,5-Difluorobromobenzene is often used as an important intermediate in organic synthesis. It can also be used as a ligand for organometallic catalysts and used in substitution reactions, coupling reactions, etc. in organic synthesis reactions.
Method:
The preparation method of 2,5-difluorobromobenzene is complex and can usually be synthesized by the following reactions:
In the presence of bromobenzene, cuprous bromide and difluoromethanesulfonamide are reacted in the presence of bromobenzene to produce 2,5-difluorobromobenzene.
Phenylmagnesium bromide is reacted with cuprous fluoride to generate 2,5-diphenyldifluoroethane, which is then subjected to bromination and iodination reactions to obtain 2,5-difluorobromobenzene.
Safety Information:
2,5-Difluorobromobenzene is irritating and can cause discomfort through inhalation, skin contact, or eye contact. Direct exposure to skin and eyes should be avoided during contact, and personal protective equipment such as protective gloves and goggles should be worn if necessary. In preparation and use, attention should be paid to fire and explosion prevention, and ensure good ventilation conditions. When using and storing, 2,5-difluorobromobenzene should be kept at a suitable temperature and in a sealed container, away from ignition, heat and oxidants.
