2 5-bis(trifluoromethyl)benzonitrile（CAS# 51012-27-2)
| Hazard Symbols | T – Toxic |
| Risk Codes | R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3276 |
| Hazard Note | Toxic |
| Hazard Class | 6.1 |
Introduction
2,5-Bis(trifluoromethyl)benzonitrile is an organic compound with the structural formula C9H4F6N2. The following is a description of its nature, use, preparation and safety information:
1. nature:
-Appearance: Colorless crystal or white crystalline powder.
-Solubility: Soluble in organic solvents such as acetonitrile and chlorinated methane.
-Melting point: about 62-64°C.
-Boiling point: about 130-132°C.
-Density: about 1.56 g/cm ^ 3.
2. use:
- 2,5-Bis(trifluoromethyl)benzonitrile can be used as a pharmaceutical intermediate for the synthesis of a variety of drugs and bioactive molecules.
-It can also be used to synthesize pesticides, dyes and polymers.
3. Preparation method:
- 2,5-Bis(trifluoromethyl)benzonitrile are synthesized in a variety of ways. One commonly used method is to react benzoyl cyanide with a trifluoromethyl compound to produce the desired product.
-Another method is to use bis (trifluoromethyl) benzene as a starting material and react with a suitable synthetic reagent, for example, the sulfinate obtained by the reaction is further reacted to obtain 2,5-Bis(trifluoromethyl)benzonitrile.
4. Safety Information:
- 2,5-Bis(trifluoromethyl)benzonitrile is irritating to the skin and eyes, please be careful to avoid contact.
-During use and storage, please pay attention to avoid inhaling dust.
-Flammable when encountering fire source, keep away from fire source and high temperature.
-It is recommended to operate in a well-ventilated place and wear appropriate protective equipment, such as chemical goggles and protective gloves.
