2 3 5-Trichloropyridine（CAS# 16063-70-0)
Risk and Safety
| Hazard Symbols | Xi – Irritant |
| Risk Codes | R52/53 – Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S61 – Avoid release to the environment. Refer to special instructions / safety data sheets. S37/39 – Wear suitable gloves and eye/face protection S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | UU0525000 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
2 3 5-Trichloropyridine（CAS# 16063-70-0) Information
| introduction | 2,3, 5-trichloropyridine is a light yellow solid and an important fine chemical intermediate. 2,3,5-trichloropyridine reacts with alkali metal hydroxide to prepare 3,5-dichloro-2-pyridine phenol, which is an important raw material for the synthesis of insecticidal mites and herbicide oxaloether. 2,3, 5-trichloropyridine can also be further fluorinated to synthesize 2, 3-difluoro-5-chloropyridine, which is the basic raw material for the synthesis of herbicide alkynurate. |
| preparation | 60g of methanol was added to a 1000mL four-mouth flask, 100g 2,3,5,6-tetrachloropyridine and 31.7g of hydrazine hydrate were added, the temperature was raised to 60-65 ℃, the heat preservation reaction was carried out for about 2 hours, the reaction was finished, the temperature was lowered to 0-5 ℃, the temperature was lowered to 1 hour, the solid was filtered, and the solid was 2,3, 5-trichlor6-hydrazinyl pyridine hydrate was dried to obtain 101.6g of white solid with 96% yield and 98.5% content. Add 100g 2,3,5-trichloro 6-hydrazinyl pyridine hydrate, 50g of 5% sodium hydroxide aqueous solution to 1000ml of four-mouth bottle, raise the temperature to 70-75 ℃, add 387.6g of 10% sodium hypochlorite aqueous solution dropwise, keep the temperature at 70-75 ℃, react for 1 hour, end the reaction, cool to 5-10 ℃, stir for 1 hour, filter to obtain 2,3, the crude 5-trichloropyridine is distilled under reduced pressure to obtain the product, which is a light yellow solid with a yield of 95% and a content of 98%. |
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