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1H-Pyrrolo[2 3-b]pyridine 6-methoxy-(CAS# 896722-53-5)

Chemical Property:

Molecular Formula C8H8N2O
Molar Mass 148.16
Density 1.244±0.06 g/cm3(Predicted)
Melting Point 88-89 °C
Boling Point 284.511°C at 760 mmHg
Flash Point 98.269°C
Vapor Presure 0.005mmHg at 25°C
pKa 14.10±0.40(Predicted)
Storage Condition Sealed in dry,Room Temperature
Refractive Index 1.647

Product Detail

Product Tags

Hazard Symbols Xn – Harmful
Risk Codes R22 – Harmful if swallowed
R36 – Irritating to the eyes
Safety Description 26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
Hazard Class IRRITANT

 

Introduction

6-methoxy-1H-cryrolo [2,3-b]pyridine is an organic compound with the chemical formula C9H8N2O. Its properties are as follows:

 

1. Appearance: 6-methoxy-1H-chrrolo [2,3-b]pyridine is colorless to yellow crystal.

2. melting point: about 105-108 ℃.

3. Boiling point: about 325 ℃.

4. Solubility: It is soluble in organic solvents such as chloroform, methanol and dimethyl sulfoxide, and slightly soluble in water.

 

6-methoxy-1H-yrrolo [2,3-b]pyridine have important uses in pharmaceutical and chemical research, such:

 

1. Drug treatment: It is widely used in the research and development of anti-tumor, anti-inflammatory, anti-cancer and other drugs.

2. Chemical synthesis: As an important intermediate in organic synthesis, it can be used to construct complex organic molecular structures.

 

Methods for preparing 6-methoxy-1H-cryrolo [2,3-b]pyridine are mainly as follows:

 

1. N-methylation reaction of indole: Indole is reacted with methyl halide to generate 6-methyl indole, and then reacted with N-methyl vinyl amine to generate 6-methoxy-1H-cryrolo [2,3-b]pyridine.

2. Redox reaction of indole: 6-methoxy-1H-pyridolo [2,3-b]pyridine can be obtained by reacting indole with sodium nitrite and tert-butyl peroxide.

 

Regarding safety information, there are few studies on the toxicity and danger of 6-methoxy-1H-pyridolo [2,3-b]pyridine, so the specific safety evaluation needs further research. When conducting experiments or applications, correct experimental operations and safety measures should be followed, avoid direct contact with skin and eyes, pay attention to protective measures, and avoid inhaling aerosols or dust. If necessary, it should be used in a well-ventilated place.


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