1H-Pyrazole-3-carboxylicacid 5-methyl-（CAS# 696-22-0)
| Hazard Symbols | Xi – Irritant |
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 – Wear suitable gloves and eye/face protection |
Introduction
It is an organic compound with the chemical formula C5H5N2O2. It is typically a colorless to pale yellow crystalline solid.
The compound has two functional groups, one is a pyrazole ring and the other is a carboxylic acid functional group. It has moderate solubility and is soluble in water and common organic solvents. The methyl group in its structure makes it hydrophobic.
As a heterocyclic compound, 5-methyl-has a variety of biological activities. It is widely used in pharmaceutical research and drug synthesis, often as a raw material or intermediate. Specific applications include the synthesis of vitamin B1 analogs, insecticides, plavix inhibitors (a compound used to inhibit plant growth), and the like.
Preparation, 5-methyl-can be obtained by reacting the nitrogen atom of the pyrazole ring with a methylating agent (e. g. methyl iodide). This method is carried out by an N-methylation reaction, the common method being the reaction of the corresponding nucleophile with an N-methyl reagent.
