1-(trifluoroacetyl)-1H-imidazole (CAS# 1546-79-8)
Risk and Safety
| Risk Codes | R10 – Flammable R36/37/38 – Irritating to eyes, respiratory system and skin. R34 – Causes burns R22 – Harmful if swallowed |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 – Wear suitable protective clothing and gloves. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S16 – Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | T |
| HS Code | 29332900 |
| Hazard Note | Flammable/Moisture Sensitive/Keep Cold |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
N-trifluoroacetimidazole. It has the following properties:
1. Appearance: N-trifluoroacetamidazole is a colorless crystalline solid.
2. Solubility: It can be dissolved in many organic solvents, such as ethanol, ethyl acetate and dimethylformamide, etc.
3. Stability: N-trifluoroacetamidazole has good stability to heat and light.
N-trifluoroacetimidazole is mainly used in the field of organic synthesis and is often used as a hydrofluorate formation reagent for organic compounds. It can be used to generate different compounds containing trifluoroacetyl groups, such as ketones and alcohols, enol ethers and esters.
The preparation methods of N-trifluoroacetamidazole are mainly as follows:
1. Chlorinate trifluoroacetic acid or sodium fluoride is reacted with imidazole to obtain the target product.
2. Trifluoroacetic anhydride is reacted with imidazole under acidic conditions to produce N-trifluoroacetylimidazole.
1. Wear appropriate protective gloves, protective glasses and protective clothing when using.
2. Avoid inhaling its dust or vapours and ensure that the operating area is well ventilated.
3. Avoid contact with skin and eyes, rinse immediately with plenty of water and seek medical treatment.
4. Keep away from fire sources and oxidants and keep them sealed when storing.
