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1-Methylxanthine(CAS#6136-37-4)

Chemical Property:

Molecular Formula C6H6N4O2
Molar Mass 166.14
Density 1.539±0.06 g/cm3(Predicted)
Melting Point ≥300°C
Solubility Aqueous Base (Slightly), DMSO (Slightly)
Appearance Solid
Color Pale Yellow to Dark Yellow
Maximum wavelength(λmax) ['270nm(H2O)(lit.)']
BRN 171507
pKa pK1:7.70;pK2:12.0 (25°C)
Storage Condition Sealed in dry,Room Temperature
Refractive Index 1.626
MDL MFCD00005561
In vitro study 1-Methylxanthine (1-MTX; 3 mM; for 30 min) increases the radiation-induced clonogenic and apoptotic cell (RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53)) death. 1-Methylxanthine (1MX) exhibits similar activities to other naturally occurring methylxanthines. Unlike caffeine, TP, and theobromine, 3-Methylxanthine (3MX) and 1-methylxanthine do not occur naturally at high levels in plants.

Product Detail

Product Tags

Hazard Symbols T+ – Very toxic
Risk Codes 26/27/28 – Very toxic by inhalation, in contact with skin and if swallowed.
Safety Description S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
WGK Germany 3
RTECS ZD8575000
HS Code 29335990

 

Introduction

1-Methylxanthine is an organic compound.It is stable at room temperature but decomposes in the presence of high temperatures, high pressure, light, and oxygen.1-Methylxanthine is a widely used compound. It is one of the main metabolites of caffeine and a commonly used biomarker. It can also be used to determine caffeine intake and to estimate the rate at which caffeine is metabolized in the body.There are several ways to prepare 1-methylxanthine. A commonly used method is to react xanthine with methyl iodide. The reaction is usually carried out under alkaline conditions, and the reactants are added to the alkaline carbonate solution, which is heated to obtain the product of 1-methylxanthine.Safety should be taken when using, storing, and handling 1-methylxanthine. It is a combustible substance and avoids contact with open flames and high temperatures. Care should be taken to prevent inhalation and contact with the skin, eyes and mucous membranes during the procedure. Wear protective glasses and gloves if necessary to ensure well-ventilated experimental conditions. When storing, it should be sealed and protected from light, away from fire sources and oxidants. If there is a leak, it should be removed with an appropriate adsorbent or solvent to avoid entering the water source and sewer.


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