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β-thujaplicin(CAS# 499-44-5)

Chemical Property:

Molecular Formula C10H12O2
Molar Mass 164.2
Density 1.0041 (rough estimate)
Melting Point 50-52°C(lit.)
Boling Point 140°C10mm Hg(lit.)
Flash Point 128.1°C
Solubility Insoluble in water
Vapor Presure 8.98E-05mmHg at 25°C
Appearance Colorless, prismatic crystals (recrystallized from anhydrous ethanol)
Color White
Merck 14,9390
pKa 7.06±0.30(Predicted)
Storage Condition Sealed in dry,Room Temperature
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.
Sensitive Avoid contact with oxides
Refractive Index 1.5190 (estimate)
MDL MFCD00059582
In vitro study In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC 50 values of 316.5 ± 35.5 and 152.5 ± 25.3 µM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT , CHST10 , and BTG4 genes.

Product Detail

Product Tags

Hazard Symbols Xn – Harmful
Risk Codes 22 – Harmful if swallowed
Safety Description 36 – Wear suitable protective clothing.
WGK Germany 3
RTECS GU4200000

 

Introduction

Hinokiol, also known as α-terpene alcohol or Thujanol, is a natural organic compound that belongs to one of the components of turpentine. Hinoylol is a colorless, transparent liquid with a fragrant pine flavor.

 

Hinokiol has a variety of uses. It is widely used in the perfume and fragrance industry to add fragrance and fragrance to products. Secondly, juniper alcohol is also used as a fungicide and preservative, and is often used in the preparation of disinfectants and fungicides.

 

There are several ways to prepare juniperol. Usually, it can be extracted by distillation of volatile oils from juniper leaves or other cypress plants, and then separated and purified to obtain juniperol. Hinoki alcohol can also be synthesized by chemical synthesis.

 

Safety information of juniperol: It is less toxic and is generally considered safe. As an organic compound, it still needs to be handled and stored correctly. Avoid contact with skin and eyes, and rinse immediately with water in case of accidental contact. It should be kept away from open flames and high temperatures, and stored in a cool, dry place.


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